Antileishmanial Effect of Allopurinol
نویسندگان
چکیده
منابع مشابه
Antileishmanial effect of allopurinol.
Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of allopurinol ribotide. Its lack of toxicity makes it a potential candidate for ani...
متن کاملAllopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.
Allopurinol ribonucleoside [4-hydroxy-1-P-D-ribofuranosylpyrazolo(3,4,-d)pyrimidine] was shown to be more effective than allopurinol in inhibiting the growth of Leishmania promastigotes in vitro. Both allopurinol and its ribonucleoside were equally effective in preventing the transformation of the intracellular form (amastigote) of Leishmania donovani to the extracellular form (promastigote). P...
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THE ANTILEISHMANIAL ACTIVITY OF THREE ORGANIC SOLVENT EXTRACTS AND WATER RESIDUE OF THE PLANTS: Acacia nilotica (Mimosaceae) (husk), Ambrosia miratima (Astraceae) (aerial shoot) and Azadarichta indica (Meliaceae) (leaves) were tested in vitro against Leishmania donovani promastigotes. The study revealed that the extracts of A. nilotica and A. miratima have effectious antileishmanial activity at...
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CROWELL, JACK, W., CARL E. JONES, AND ELVIN E. SMITH. Effect oj allopurinol on hemorrhagic shock. Am. J. Physiol. 216(4) : 744-748. 1969.-Five groups of ten dogs each were hemorrhaged until their arterial pressure was 30 mm Hg, and this arterial level maintained until 20 % of the shed blood had returned to the animal. The remaining blood was then reinfused. Groups 1 and If were used to determin...
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BACKGROUND It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with all...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1974
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.5.5.469